Homologation Reactions

Reagents, Applications, and Mechanisms

Vittorio Pace, Vittorio Pace

• Verlag: Wiley-VCH
• Jahr: 2023
• ISBN:
  9783527830220
• Auflage: 1
• Thema: Physical Sciences
• Thema: Organic Chemistry

Provides a unique summary of homologation strategies in organic synthesis

Homologation Reactions presents different concepts underpinning the use of homologating reagents as well as their applications in organic synthesis. It covers in-depth discussions on the rationales governing this kind of transformations with a strong emphasis on mechanistic elements modulating critical aspects (e.g. selectivity) of the processes. In addition, this two-volume work features:

• Metal carbenoids, ylides, and diazo reagents
• Homologating agents working under nucleophilic, electrophilic, and radical regime
• Homologations realized on boron-containing or carbon-centered linchpins
• Use of highly sensitive fluorinated homologating agents
• Progressive homologations and the concept of assembly line synthesis
• Homologation processes followed by rearrangement cascades
• Construction of cyclic motifs and ring-expansion
• Homologation reactions with carbon monoxide and carbon dioxide
• New and/or challenging directions to expect in the future

Written by an international team of leaders in the field, the book is a useful guide for designing effective transformations by using homologation reactions. It is a must-read for every synthetic chemist in academia and industry!