Fibrin formation and Fibrinolysis

April, 2–3, 1985, London, England

D. A. Lane

• Verlag: De Gruyter
• Jahr: 2019
• ISBN drucken:
  9783110105971
• eBook-ISBN:
  9783110871951
• Thema: Medicine
• Thema: Biochemistry in Medicine

Keine ausführliche Beschreibung für "Fibrin formation and Fibrinolysis" verfügbar.

Inhaltsverzeichnis

• Preface
• Contributors
• Contents
• I. Synthesis And Assembly
• A scheme for the intracellular assembly of human fibrinogen
• Evidence that platelet and plasma fibrinogen have the same A-alpha chain gene product
• Fibrinopeptide A and the phosphorylation of fibrinogen
• II. Structure and Function
• Size and shape of the fibrinogen molecule: crystalline forms of native and modified human fibrinogen
• The C-terminal polymerisation domain of fibrinogen
• γ- Chain Crosslinking Of Fibrin At Dd-Trans Contact
• Soluble fibrin contains fibrin polymers of different molecular weight. Ultracentrifugation studies at 37°C
• Relationship of final thickness of fibrin fibers to maximal rate of assembly and to fibrinopeptide B release
• III. Congenital Variants
• Fibrinogen New York 1: The structural, functional, and genetic defects and an hypothesis of the role of fibrin in the regulation of coagulation and fibrinolysis
• Fibrinogen Pontoise - a genetically abnormal fibrinogen with defective fibrin polymerisation but normal fibrinopeptide release
• Fibrinogen Milano I: Abnormal fibrin polymerization related to a carboxy-terrainal defect of the γ-chain (γ-330 Asp Val)
• Fibrinogen "Bergamo I" (Λα 16 Arg - Cys): Alternative methods for structure elucidation
• Screening small plasma samples by HPLC for abnormalities of fibrinopeptide release
• Iv. Fibrin(ogen) And Fibrinolysis
• On the role of fibrin in the fibrinolytic system
• Isolation and characterisation of plasmic degradation products of fibrinogen by high-performance liquid chromatography
• The acceleration of tissue-type plasminogen activator (t-PA)-mediated activation of plasminogen by fibrinogen cyanogen bromide fragments is species specific
• Role of fibrin polymerization in fibrinolysis: Comparison between polymerisable and unpolymerisable fibrins in the potentiating effect of plasminogen activation by tissue-type plasminogen activator (tpA)
• Role of fibrin and its degradation products in the activation of plasminogen by streptokinase and urokinase
• V. Interactions With Cells
• The role of fibrinogen in platelet aggregation
• Platelet-associated fibrinogen: Conformational change of fibrinogen induced by its adsorption to platelet-surface
• Migration of cultured endothelial cells in response to fibrinogen
• Characteristics of the interactions of fibrinogen and soluble fibrin with cultured endothelial cells
• Mechanism of fibrin-induced disorganisation of cultured human endothelial cells
• The fibrinogen: red cell interaction and its influence on blood rheology
• Haemorheologic effects of plasmin and thrombininduced fibrinogen derivatives: An in vitro study
• Binding of human fibrinogen to streptococci and its role in streptococcal pathogenicity
• VI. Assays To Fibrin(ogen) Fragments And Their Use
• Discrimination between fibrin and fibrinogen by a monoclonal antibody against a synthetic hexapeptide representing the amino-terminus of the alpha-chain of fibrin
• A new enzyme immunoassay of fibrin(ogen) degradation products in plasma using a monoclonal antibody
• Fibrin(ogen) degradation products. Determination using a monoclonal anti D neo antibody. Advantages in clinical investigation
• A monoclonal antibody, specific for human fibrinogen and fibrinopeptide A-containing fragments. Its application in an enzyme-immunoassay for fibrinogen degradation products, suitable for use in plasma
• A monoclonal antibody against the CNBr-peptide F-CB3 of the Aα-chain of human fibrinogen
• Clinical aspects of fibrin formation and fibrinolysis measured with monoclonal antibodies against D-dimer
• Fibrinogen derivatives in acute stroke
• VII. Fibrin(ogen) And Disease Pathology
• Triggering of the extrinsic blood coagulation system
• Extravascular fibrin formation and fibrinolysis in a model of inflammation accompanying cellular hypersensitivity
• Extra-vascular fibrin deposition in cellular hypersensitivity - the role of T lymphocyte-macrophage interactions
• Fibrinolytic studies in disorders of connective tissue
• Soluble fibrin/fibrinogen related antigen in human intima in relation to atherogenesis
• Fibrinogen as a possible risk factor for IHD in the Caerphilly study
• VIII. Appendix: Data On Fibrinogen
• Fibrinogen amino acid sequences
• Author Index
• Subject Index