Systems Biology of Cell Signaling
Recurring Themes and Quantitative Models
James Ferrell
- 264 pages
- English
- ePUB (adapté aux mobiles)
- Disponible sur iOS et Android
Systems Biology of Cell Signaling
Recurring Themes and Quantitative Models
James Ferrell
Ă propos de ce livre
How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and nonlinear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations. This textbook seeks to provide quantitatively inclined biologists and biologically inclined physicists with the tools and insights needed to apply modeling and theory to interesting biological processes.
Key Features:
- Full-color illustration program with diagrams to help illuminate the concepts
- Enables the reader to apply modeling and theory to the biological processes
- Further Reading for each chapter
- High-quality figures available for instructors to download
Foire aux questions
Informations
1
INTRODUCTION
IN THIS CHAPTER . . .
- 1.1 SIGNAL TRANSDUCERS ARE CELLULAR COMPONENTS THAT ACT MAINLY BY REGULATING OTHER CELLULAR COMPONENTS
- 1.2 THE SIGNAL TRANSDUCTION PARTS LIST IS LONG
- 1.3 SIGNAL TRANSDUCTION IN BACTERIA IS ACCOMPLISHED BY SHORT, (MOSTLY) LINEAR, (MOSTLY) NON-INTERCONNECTED PATHWAYS
- 1.4 THE EGFR SYSTEM IS DEEP, INTERCONNECTED, AND COMPLICATED
- 1.5 COMPLICATED SYSTEMS CAN BE SIMPLIFIED BY ASSUMING MODULARITY
- 1.6 ORDINARY DIFFERENTIAL EQUATIONS PROVIDE A POWERFUL FRAMEWORK FOR UNDERSTANDING MANY SIGNALING PROCESSES
- 1.7 THEORY CAN HELP HIGHLIGHT THE COMMONALITIES OF DIVERSE BIOLOGICAL PHENOMENA
- 1.8 SIX BASIC TYPES OF RESPONSE ARE SEEN OVER AND OVER AGAIN IN CELL SIGNALING
- 1.9 FIVE OR SIX BASIC CIRCUIT MOTIFS ARE SEEN OVER AND OVER AGAIN IN SIGNALING SYSTEMS
- SUMMARY
- MOVING FORWARD
- FURTHER READING
U.S. Prescriptions (millions) | ||||||||
---|---|---|---|---|---|---|---|---|
Drug | Indications | Mechanism of Action | 2014 | 2015 | 2016 | 2017 | 2018 | |
1 | Atorvastatin | High cholesterol | Inhibits cholesterol synthesis | 74 | 94 | 97 | 105 | 112 |
2 | Levothyroxine | Hypothyroidism | Activates thyroid hormone receptors | 100 | 113 | 114 | 102 | 105 |
3 | Lisinopril | Hypertension | Inhibits the last step in the production of the hormone angiotensin II | 114 | 110 | 109 | 104 | 97 |
4 | Metformin | Type II diabetes mellitus | Inhibits mitochondrial respiratory-chain complex 1 | 85 | 83 | 80 | 78 | 84 |
5 | Amlodipine | Hypertension, angina pectoris | Inhibits voltage-gated calcium channels | 63 | 71 | 75 | 73 | 76 |
6 | Metoprolol | Hypertension, angina pectoris, and myocardial infarction | Inhibits ÎČ1-adrenergic receptors | 71 | 69 | 73 | 67 | 71 |
7 | Albuterol | Asthma and chronic obstructive pulmonary disease | Activates ÎČ2-adrenergic receptors | 48 | 50 | 47 | 50 | 61 |
8 | Omeprazole | Gastroesophageal reflux disease and gastric ulcers | Inhibits H+/K+ ATPase | 71 | 71 | 70 | 58 | 58 |
9 | Losartan | Hypertension | Inhibits angiotensin II receptors | 37 | 47 | 49 | 52 | 51 |
10 | Simvastatin | High cholesterol | Inhibits cholesterol synthesis | 97 | 89 | 80 | 73 | 66 |