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About this book
Sutures are more than just fibrous joints between the bones in our skull. They are active growth sites that influence the development, growth and shaping of our face and cranium. When suture development is disrupted, craniosynostosis can result, a condition which is characterized by the premature closure of one or more cranial sutures before brain growth is complete and leads to an abnormally shaped skull. In this publication, leading experts in the field, both researchers and clinicians, discuss suture morphogenesis from developmental, evolutionary and genetic perspectives. In addition, an appraisal of the molecular etiology, clinical presentation and treatment of craniosynostosis is presented, as well as an outlook to future areas of study and to innovative therapeutic philosophies. In this volume craniofacial developmental and evolutionary biologists, oral and maxillofacial surgeons, orthodontists as well as pediatric and plastic surgeons will find a wealth of recent information on the field of craniofacial development, deformity and its treatment.
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Table of contents
- Cover
- Contents
- Foreword
- Preface
- Developmental Anatomy of Craniofacial Sutures
- Locate, Condense, Differentiate, Grow and Confront: Developmental Mechanisms Controlling Intramembranous Bone and Suture Formation and Function
- Mechanical Influences on Suture Development and Patency
- Suture Neontology and Paleontology: The Bases for Where, When and How Boundaries between Bones Have Been Established and Have Evolved
- Single Suture Craniosynostosis: Diagnosis and Imaging
- Clinical Features of Syndromic Craniosynostosis
- Genetics of Craniosynostosis: Genes, Syndromes, Mutations and Genotype-Phenotype Correlations
- Roles of FGFR2 and Twist in Human Craniosynostosis: Insights from Genetic Mutations in Cranial Osteoblasts
- Fibroblast Growth Factor Signaling in Cranial Suture Development and Pathogenesis
- Tgf-β Regulation of Suture Morphogenesis and Growth
- The Bmp Pathway in Skull Vault Development
- Current Treatment of Craniosynostosis and Future Therapeutic Directions
- Author Index
- Subject Index