Neurology

A Queen Square Textbook

Charles Clarke, Robin Howard, Martin Rossor, Simon Shorvon, Charles Clarke, Robin Howard, Martin Rossor, Simon Shorvon

• Publisher: Wiley-Blackwell
• Year: 2016
• Print ISBN: 9781118486177
• eBook ISBN: 9781118486139
• Edition: 2
• Topic: Medicine
• Subtopic: Neurology

Neurology: A Queen Square Textbook, second edition, is a fully revised and updated companion that demonstrates the rapid pace of advancement within clinical neurology and applied neuroscience

• A comprehensive and practical overview of current developments within clinical neurology, synthesising clinical neurology with translational research
• Expertly edited and written by neurologists, neuroscientists and neurosurgeons working at Queen Square, advised by an distinguished International Editor team to present a global perspective
• Introductory chapters summarise the basic sciences underpinning the practice of clinical neurology, including genetics, channelopathies, immunology, neurophysiology and neuropathology
• All chapters fully revised and updated to reflect the increasing role of neurologists in acute care
• Includes new contributions concerning major developments in the care of; stroke, epilepsy, dementia, Parkinson's disease, multiple sclerosis, neuromuscular disease, headache, infections, spinal disease, cranial nerve disease, neuropsychiatry, neurogenetics, neuro-oncology, uroneurology, neuro-otology, neuro-ophthalmology, pain medicine, sleep medicine, metabolic disease, drugs and toxins, autonomic disease, systemic disease, and neurorehabilitationfor dementia, epilepsy, headaches, neuro-genetics and many more

CHAPTER 1
Neurology Worldwide: The Epidemiology and Burden of Neurological Disease

Simon Shorvon

UCL Institute of Neurology

Neurological disease casts a heavy shadow over the lives of the patient, their family and friends and over society. In a recent survey, in Europe about one‐third of all burden of disease was caused by brain disease – 23% of the years of healthy life is lost (YLL), 50% of years lived with disability (YLD) and 35% of disability‐adjusted life years (DALYs). The aim of all neurological services must be to alleviate the suffering associated with the disease, and to realise this aim the rational planning of such health services requires epidemiological knowledge in five broad areas:

1. Epidemiology of the condition – its frequency and distribution within a population, its causation, mortality and co‐morbidity.
2. Broad impact of the disease (the ‘burden of illness’) on individuals, families, health services and societies and also its financial cost.
3. Effectiveness and cost‐effectiveness of diagnosis, investigation and treatment.
4. Existing health care resources – their distribution and priorities, and the potential for prevention.
5. Prognosis and outcome, via cohort studies and case–control studies.

The last three areas are outside the scope of this chapter; here an overview of selected issues related to the epidemiology and burden of neurological illness is given and, as this book is based on practice at Queen Square, here too I emphasise studies from the National Hospital for Neurology and Neurosurgery and the UCL Institute of Neurology. These set the scene for the more detailed consideration of neurological disease contained in the rest of the volume.

Epidemiology of neurological disease

It is self‐evident that knowledge of epidemiology is important to underpin any decision about the provision of health care resources. It is also clear that epidemiological data (on frequency, distribution, mortality, etc.) are of little practical value unless related to an intervention or therapeutic advance. Sadly, however, in practice, even where reliable data exist, these are used only inconsistently in planning health care. Neurological disease is one example of this depressing fact, for the amount of education and expenditure is far below its estimated impact. In many, indeed perhaps most, health care settings, the provision of facilities for neurological care is often surprisingly fragmented and inappropriately targeted, even where, as in the United Kingdom, there is a nationwide health service.

Frequency and distribution of neurological disease

Incidence and prevalence rates are the most common measures of frequency used in medicine.

Incidence is a measure of the rate at which new cases occur in a specified population during a specified period. The incidence rate is usually calculated as the number of new cases occurring per 100 000 of the general population per year.

Prevalence is defined as proportion of a population that are cases at a point in time. The prevalence rate is usually calculated as the number of existing cases per 1000 of the general population. Point prevalence is calculated as the number on a particular day (prevalence day) and period prevalence is calculated as the number in a population over a specified period of time. Lifetime prevalence is defined as the risk of acquiring the condition at any time during life and is another important figure.

For many neurological diseases, information on even these basic measures is incomplete. Furthermore, the frequency of many neurological disorders varies markedly in different geographical regions, differs in urban when compared with rural settings, may differ with ethnicity, and is often linked to lifestyle and socio‐economic factors.

In most neurological illnesses there are also striking differences in frequency at different ages, and so the age distribution of the population will affect the frequency, and some diseases have marked gender differences. For these reasons, age‐specific or sex‐specific rates, or frequency estimates in restricted age ranges, are generally more informative than crude rates. For instance, the annual incidence of stroke in a general population is about 190/100 000/year, but in the population over 65 years the rate is 1100/100 000/year. Similarly, the incidence and prevalence of Parkinson’s disease in the general population are 20/100 000/year and 2/1000, and in those over 65 years are 160/100 000/...

Table of contents

• Cover
• Title Page
• Table of Contents
• Editorial Team
• Beginnings
• Foreword to the First Edition
• Foreword to the Second Edition
• Preface
• Acknowledgements
• CHAPTER 1: Neurology Worldwide: The Epidemiology and Burden of Neurological Disease
• CHAPTER 2: Nervous System Structure and Function
• CHAPTER 3: Mechanisms of Neurological Disease: Genetics, Autoimmunity and Ion Channels
• CHAPTER 4: The Language of Neurology
• CHAPTER 5: Stroke and Cerebrovascular Diseases
• CHAPTER 6: Movement Disorders
• CHAPTER 7: Epilepsy and Related Disorders
• CHAPTER 8: Dementia and Cognitive Impairment
• CHAPTER 9: Infection in the Nervous System
• CHAPTER 10: Nerve and Muscle Disease
• CHAPTER 11: Multiple Sclerosis and Demyelinating Diseases
• CHAPTER 12: Headache
• CHAPTER 13: Cranial Nerve Disorders
• CHAPTER 14: Neuro-Ophthalmology
• CHAPTER 15: Neuro-Otology
• CHAPTER 16: Spinal Column and Spinal Cord Disorders
• CHAPTER 17: Cerebellar Ataxias and Related Conditions
• CHAPTER 18: Restorative Neurology, Rehabilitation and Brain Injury
• CHAPTER 19: Toxic, Metabolic and Physical Insults to the Nervous System and Inherited Disorders of Metabolism
• CHAPTER 20: Disorders of Consciousness, Intensive Care Neurology and Sleep
• CHAPTER 21: Neuro-Oncology
• CHAPTER 22: Neuropsychiatry
• CHAPTER 23: Pain
• CHAPTER 24: Autonomic Aspects of Neurology
• CHAPTER 25: Uroneurology
• CHAPTER 26: Systemic Conditions and Neurology
• Index
• End User License Agreement