Introduction to Strategies for Organic Synthesis

Laurie S. Starkey

• Publisher: Wiley
• Year: 2018
• Print ISBN: 9781119347248
• eBook ISBN: 9781119347217
• Edition: 2
• Topic: Physical Sciences
• Subtopic: Chemistry
• Index: Chemistry

Bridging the Gap Between Organic Chemistry Fundamentals and Advanced Synthesis Problems

Introduction to Strategies of Organic Synthesis bridges the knowledge gap between sophomore-level organic chemistry and senior-level or graduate-level synthesis to help students more easily adjust to a synthetic chemistry mindset. Beginning with a thorough review of reagents, functional groups, and their reactions, this book prepares students to progress into advanced synthetic strategies. Major reactions are presented from a mechanistic perspective and then again from a synthetic chemist's point of view to help students shift their thought patterns and teach them how to imagine the series of reactions needed to reach a desired target molecule.  

Success in organic synthesis requires not only familiarity with common reagents and functional group interconversions, but also a deep understanding of functional group behavior and reactivity.  This book provides clear explanations of such reactivities and explicitly teaches students how to make logical disconnections of a target molecule.

This new Second Edition of Introduction to Strategies for Organic Synthesis:

• Reviews fundamental organic chemistry concepts including functional group transformations, reagents, stereochemistry, and mechanisms
• Explores advanced topics including protective groups, synthetic equivalents, and transition-metal mediated coupling reactions
• Helps students envision forward reactions and backwards disconnections as a matter of routine
• Gives students confidence in performing retrosynthetic analyses of target molecules Includes fully-worked examples, literature-based problems, and over 450 chapter problems with detailed solutions
• Provides clear explanations in easy-to-follow, student-friendly language
• Focuses on the strategies of organic synthesis rather than a catalogue of reactions and modern reagents

The prospect of organic synthesis can be daunting at the outset, but this book serves as a useful stepping stone to refresh existing knowledge of organic chemistry while introducing the general strategies of synthesis. Useful as both a textbook and a bench reference, this text provides value to graduate and advanced undergraduate students alike.

Table of contents

• COVER
• TITLE PAGE
• TABLE OF CONTENTS
• PREFACE
• ACKNOWLEDGMENTS
• CHAPTER 1: SYNTHETIC TOOLBOX 1
• CHAPTER 2: SYNTHETIC TOOLBOX 2
• CHAPTER 3: SYNTHESIS OF MONOFUNCTIONAL TARGET MOLECULES (1-FG TMs)
• CHAPTER 4: SYNTHESIS OF TARGET MOLECULES WITH TWO FUNCTIONAL GROUPS (2-FG TMs)
• CHAPTER 5: SYNTHESIS OF AROMATIC TARGET MOLECULES
• CHAPTER 6: SYNTHESIS OF COMPOUNDS CONTAINING RINGS
• CHAPTER 7: PREDICTING AND CONTROLLING STEREOCHEMISTRY
• CHAPTER 8: TRANSITION METAL-MEDIATED CARBON–CARBON BOND FORMATION
• SOLUTIONS TO PROBLEMS
• INDEX
• END USER LICENSE AGREEMENT