RNA Therapeutics

The Evolving Landscape of RNA Therapeutics

Paloma H. Giangrande, Vittorio de Franciscis, John J. Rossi, Paloma H. Giangrande, Vittorio de Franciscis, John J. Rossi

• Verlag: Academic Press
• Jahr: 2022
• ISBN:
  9780128217399
• Thema: Biowissenschaften
• Thema: Molekularbiologie

RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies.

Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development.

• Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies
• Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics
• Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects