Cell Biology E-Book

Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz, Graham Johnson

• Éditeur: Elsevier
• Année: 2016
• ISBN:
  9780323400022
• Édition: 3
• Sujet: Ciencias biológicas
• Sous-sujet: Biología celular

The much-anticipated 3rd edition of Cell Biology delivers comprehensive, clearly written, and richly illustrated content to today's students, all in a user-friendly format. Relevant to both research and clinical practice, this rich resource covers key principles of cellular function and uses them to explain how molecular defects lead to cellular dysfunction and cause human disease. Concise text and visually amazing graphics simplify complex information and help readers make the most of their study time.

• Clearly written format incorporates rich illustrations, diagrams, and charts.
• Uses real examples to illustrate key cell biology concepts.
• Includes beneficial cell physiology coverage.
• Clinically oriented text relates cell biology to pathophysiology and medicine.
• Takes a mechanistic approach to molecular processes.

• Major new didactic chapter flow leads with the latest on genome organization, gene expression and RNA processing.
• Boasts exciting new content including the evolutionary origin of eukaryotes, super resolution fluorescence microscopy, cryo-electron microscopy, gene editing by CRISPR/Cas9, contributions of high throughput DNA sequencing to understand genome organization and gene expression, microRNAs, IncRNAs, membrane-shaping proteins, organelle-organelle contact sites, microbiota, autophagy, ERAD, motor protein mechanisms, stem cells, and cell cycle regulation.
• Features specially expanded coverage of genome sequencing and regulation, endocytosis, cancer genomics, the cytoskeleton, DNA damage response, necroptosis, and RNA processing.
• Includes hundreds of new and updated diagrams and micrographs, plus fifty new protein and RNA structures to explain molecular mechanisms in unprecedented detail.

Index

Page numbers followed by “f” indicate figures, “t” indicate tables, and “b” indicate boxes.

A

A kinase-anchoring proteins (AKAPs), 429

A site of tRNAs, 213

AAA ATPase family, 623, 623f, 625b, 636f

Aa-tRNA synthetases, Aminoacyl-tRNA (aa-tRNA) synthetases

A-band, 673f

Abasic sites, 750

ABC transporters, 244t, 250–252, 250f–251f, 346–347, 347f

degradation by proteasomes and, 401

protein translocation across plasma membrane by, 311, 314f

type I, 314f, 315

ABP-280, 590t–591t

Abp1p, 590t–591t

Abscission, 771f, 775–776, 776f–777f

Accidental cell death, 798, 798b

programmed cell death vs., 797–800, 797f–800f

Acetylated N-terminus, 34f

Acetylcholine (ACh), 291f, 295

neuromuscular junctions and, 294

skeletal muscle contraction and, 678

Acetylcholine (ACh) receptors, 294

muscarinic, 293–294

nicotinic, 273–275, 274f, 279

Acetylcholinesterase, 294

Acetyl-CoA, 319, 321f

ACh, Acetylcholine (ACh)

ACh receptors, Acetylcholine (ACh) receptors

Achiasmate segregation, 785

Acrosomal process, 652f, 666f

Actin, 575–576, 576f

bulk movement of cytoplasm driven by, 647–648, 648f–649f

contractile ring of, 771–772

critical concentration of, 579–580

dynamics of, in live cells, 585–588, 586b, 586f, 588f

evolution of, 577–578, 578f

molecule of, 577, 577f

movements of organelles based on, 648–649, 649f

polymerization of, 579–58...