Drug Transporters

Molecular Characterization and Role in Drug Disposition

Guofeng You, Marilyn E. Morris, Binghe Wang, Guofeng You, Marilyn E. Morris

• Éditeur: Wiley
• Année: 2022
• ISBN:
  9781119739876
• Édition: 3
• Sujet: Medizin
• Sous-sujet: Pharmakologie

DRUG TRANSPORTERS

Drug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters

Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.

The updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases.

• Reflects the current state of the field and offers perspectives on future directions
• Covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science
• Provides up-to-date information on drug transporter families, mechanisms, and clinical implications
• Includes extensive references and numerous figures and tables throughout

Understandable for novices while offering sufficient depth for more experienced researchers, Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.

INDEX

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• ABCB1, 199, 259, 362–364, 380–382
• ABCB4, 199, 259
• ABCB11, 192–193, 259
• ABCC1, 225, 260
• ABCC2, 224, 225, 259
• ABCC3, 225, 260
• ABCC4, 225–226, 260
• ABCC5, 226, 260
• ABCC6, 224, 226, 260
• ABCC10, 226
• ABCC11, 224–226
• ABCC/MRP proteins
  • drug resistance profiles of, 221–223
  • drug transporter, 217, 223
  • efflux transporters, 217
  • expression and localization of, 215, 217–221
  • genetic variants, 213, 214, 223–226
  • human cancer, 215, 217–221
  • interindividual variability of, 215, 217
  • molecular characterization, 215
  • nomenclature, 215
  • substrate specificity of, 221–223
  • susceptibility to complex disease, 225–226
  • topology of, 216
• ABCCs, 366
• ABCG2, 259, 364–366, 382see also breast cancer resistance protein (BCRP)
  • cancer, 244–246
  • discovery and nomenclature, 235
  • drug resistance, 244–246
  • expression, 236–237, 242–244
  • gene, 236
  • genetic polymorphisms, 246–248
  • Jr(a) phenotype, 242
  • structural characterization of, 239
  • substrates and inhibitors of, 242
  • urate and gout, 241–242
• ABCP gene, 235
• ABC transporters see ATP‐binding cassette (ABC) transporters
• abiraterone, 100
• absorption, distribution, clearance, and elimination (ADCE), 444, 445
• absorption, distribution...