
Capillary Electrophoresis Methods for Pharmaceutical Analysis
- 546 pages
- English
- PDF
- Available on iOS & Android
Capillary Electrophoresis Methods for Pharmaceutical Analysis
About this book
Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control.- Provides current status and future developments in CE analysis of pharmaceuticals.- Explains how to develop and validate methods.- Includes major pharmaceutical applications including assays and impurity testing.
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Information
Table of contents
- Front cover
- Capillary Electrophoresis methods for Pharmaceutical analysis
- Copyright page
- Contents
- Preface
- Contributors
- Chapter 1. Overview of capillary electrophoresis in pharmaceutical analysis
- Chapter 2. Theoretical considerations in performance of various modes of CE
- Chapter 3. Equipment considerations for capillary electrophoresis
- Chapter 4. Method development for pharmaceutical analysis
- Chapter 5. Role of CE in drug substance and drug product development
- Chapter 6. General considerations to improve performance of CE methods
- Chapter 7. Overview of current regulatory guidance
- Chapter 8. Qualification of CE instrumentation
- Chapter 9. Robustness testing of CE methods
- Chapter 10. Validation of analytical methods using capillary electrophoresis
- Chapter 11. The need for CE methods in pharmacopoeial monographs
- Chapter 12. CE in impurity profiling of drugs
- Chapter 13. Ion analysis using capillary electrophoresis
- Chapter 14. Role of CE in biopharmaceutical development and quality control
- Chapter 15. Capillary electrophoresis and bioanalysis
- Chapter 16. CE as an orthogonal technique to chromatography
- Chapter 17. Capillary electrochromatography of pharmaceuticals
- Chapter 18. Coupling CE and microchip-based devices with mass spectrometry
- Index