Genome Editing
eBook - ePub

Genome Editing

A Practical Guide to Research and Clinical Applications

  1. 230 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Genome Editing

A Practical Guide to Research and Clinical Applications

About this book

Genome Editing: A Practical Guide to Research and Clinical Applications is geared towards investigators interested in learning how to use CRISPR-Cas9-based technologies, with a focus on cardiovascular research and clinical applications. Covering a range of topics from the basics of genome editing to design considerations, to assessments and applications, this reference allows readers to get started and establish a full workflow from the beginning of the project to its full completion. With worked examples drawn from real-life experiments, as well as troubleshooting and pitfalls to avoid, the book serves as an essential reference for researchers and investigators in both cardiovascular and biomedical research. - Help readers familiarise with the variety of genome-editing approaches that are being applied in cardiovascular research and medicine, i.e., both research applications and clinical applications - Understand the use of genome editing through worked examples (based on real-life experiments) in which CRISPR-Cas9 is employed, online tools to design CRISPR-Cas9 reagents, methods to interpret data from genome-editing experiments, the downsides of genome-editing technology - both the scientific and ethical pitfalls to avoid - Written in an easy-to-follow manner, guiding readers from the design of the project to its completion - Includes unpublished and new methods

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Yes, you can access Genome Editing by Kiran Musunuru in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Biology. We have over one million books available in our catalogue for you to explore.

Information

Table of contents

  1. Cover
  2. Title page
  3. Table of Contents
  4. Copyright
  5. Dedication
  6. Contents
  7. Preface
  8. List of Illustrations
  9. Chapter 1 : A brief history and primer on genome editing
  10. Chapter 2 : Choosing a genome editing strategy and target site
  11. Chapter 3 : Choosing a nuclease, guide RNA, and repair template
  12. Chapter 4 : Assessing the outcomes of genome editing
  13. Chapter 5 : Assessing for off-target mutagenesis
  14. Chapter 6 : Base editing
  15. Chapter 7 : Alternative types of editing
  16. Chapter 8 : Genome editing for cellular disease modeling
  17. Chapter 9 : Genome editing for functional experiments and screens
  18. Chapter 10 : Therapeutic genome editing
  19. Index
  20. A