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Chemistry of Nucleic Acids
Harri Lönnberg
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Chemistry of Nucleic Acids
Harri Lönnberg
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1 Nucleosides: structure, nomenclature and solution equilibria
1.1 Nomenclature
Nucleosides, the monomeric constituents of nucleic acids, are N-glycosylated derivatives of two different categories of heteroaromatic nitrogen bases, namely monocyclic pyrimidines and bicyclic purines. The pyrimidine bases are cytosine, uracil and thymine, and the purine bases are adenine and guanine. Uracil occurs only in RNA and thymine in DNA, while the other bases are common for both types of nucleic acids. The structures and enumeration of these canonical nucleic acid bases and nucleosides are depicted in Figure 1.1. As indicated, the glycosyl group is attached to N1 of pyrimidine bases and N9 of purine bases. The enumeration of the glycosyl moiety starts from the anomeric carbon, that is, the carbon atom bound to the nucleobase, not from the ring oxygen. In ribonucleosides (constituents of RNA), the glycosyl moiety is ÎČ-d-ribofuranosyl group and in 2âČ-deoxyribonucleosides (constituents of DNA) 2-deoxy-ÎČ-d-erythro-pentofuranosyl group. The latter group is often called 2-deoxy-ÎČ-d-ribofuranosyl group, but this name is not consistent with the nomenclature of carbohydrates [1]. The prefix âriboâ refers to a sugar having three stereogenic centers in addition to the anomeric (C1âČ) carbon. 2-Deoxypentoses contain only two nonanomeric stereogenic centers; hence, the correct prefixes are âerythroâ and âthreo.â The names of ribonucleosides are derived from the names of their base moieties: adenosine, guanosine, cytidine and uridine. The names of 2âČ-deoxyribonucleosides have, in turn, been formed from the names of the respective ribonucleosides by a prefix 2âČ-deoxy, with the exception of thymine derivative. This 2âČ-deoxyribonucleoside is for historical reasons called just thymidine.
The names of substituted or modified nucleosides are derived from the names of the parent nucleosides, as exemplified by a few illustrative examples in Figure 1.2. Substituents on the sugar and base moiety of nucleosides are indicated in the beginning of the name in alphabetical order. A missing ring nitrogen is indicated by a prefix âdeazaâ and an extra ring nitrogen by a prefix âaza.â One should, however, note that this kind of nomenclature is applicable only as long as the sugar moiety is a five-membered d-sugar having a ribo (for ribonucleosides) or erythro configuration (for 2âČ-deoxyribonucleosides) and the anomeric configuration is ÎČ. If the configuration of the sugar moiety, enantiomeric form or ring size, is changed, the name of the nucleoside is formed by adding the name of the sugar moiety as a substituent to the name of the base moiety. This is also the case when the base moiety is heavily modified. The compound is then named as a glycosylated heterocyclic compound. Sometimes abbreviations such as ara-, lyxo- or xylo-adenosine are used. This means that the sugar moiety still is a ÎČ-d-glycofuranosyl group, but the configuration is not any more ribo. In case the sugar ring has been opened by cleaving a CâC bond, the site of the missing bond is indicated by a prefix âseco,â for example, 2âČ,3âČ-seco-adenosine. In addition, some noncanonical nucleobases and nucleosides have trivial names that are commonly used. The N2-deamino analogs of guanine and guanosine are called hypoxanthine and inosine, respectively, and the 2-oxo derivatives of these are known as xanthine and xanthosine.
1.2 Cyclonucleosides
Cyclonucleosides are synthetic analogs of nucleosides having an additional covalent linkage between the sugar and base moiety. Only one cyclonucleoside, 3,5âČ-anhydro-xanthosine, has bee...