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What is Cancer?
JILL COOPER
Cancer is a general term applied to tumours or growths. The terms oncology, anaplasia, neoplasms may all be used as an alternative to the word cancer. Body cells normally regenerate and die continually so the number of cells remains constant. Cancer is the disordered and uncontrolled growth of cells within a specific organ or tissue type. If left untreated, they grow steadily resulting in a mass, tumour or growth. The tumour may be benign or malignant. Benign tumours grow slowly and do not recur after excision. They can still be life-threatening if untreated as they can affect vital organs. They are usually curable if they are treated early.
The human body is made up of 10 trillion cells (Knight, 2004), and there are over 100 different types of cells. 25 million cells are replaced every second in adult life. All cells replicate themselves, usually 50–60 times before cell death. Malignant cells grow in an irregular pattern (Gabriel, 2004, p. 4). The smallest detectable tumour is approximately 1 cm in diameter and already contains 1 billion cells. Normal cells know when to grow, to specialize (differentiate), to die (apoptosis), to release certain products or proteins needed by other cells to grow and how to build complex tissue structures.
Cancer is not a single disease but a complex sequence of events (Haylock, 1998). Cancers not only develop at a single site, but also result from malignant change within a single clone, or cluster, of cells. This then multiplies and acquires different changes that give it a survival chance over its neighbours. Cancer cells develop when they have defects in regulation that govern normal cell proliferation and homeostasis, i.e. they lose the ability to die and continue to multiply.
Tobias and Eaton (2001) describe how several steps are required before a normal cell becomes a malignant one. Cell growth and division is profoundly influenced by the presence of critical genes. Oncogenes drive the cell towards malignancy and suppressor genes mutate and result in a loss of normal regulatory or restraining function.
Woodhouse et al. (1997) describe the process by which cancer cells spread or metastasize:
- angiogenesis: the generation of blood vessels around the primary tumour that increases the chances for tumour cells to reach the blood stream and colonize in secondary sites;
- attachment or adhesion: tumour cells need to attach themselves to other cells and/or cell matrix proteins;
- invasion: tumour cells move across the normal barriers imposed by the extracellular matrix;
- tumour cell proliferation: new colony of tumour cells is stimulated to grow at a secondary site.
Malignant tumours, therefore, infiltrate and destroy the normal tissues surrounding them and spread to other sites either by blood or the lymphatic system. These are then called metastases or secondaries.
Although terminal and palliative care are phrases often used interchangeably, terminal actually refers to individuals who are actively dying so likely to be in the last few days of life. A diagnosis of cancer does not necessarily mean that the disease will become terminal and the phrase terminal illness can refer equally well to the end stages of neurological, viral or respiratory illness.
Palliation refers to the alleviation of symptoms rather than the attempt to cure disease and it is associated with the advanced stages of all diseases including cancer and HIV/AIDS. The World Health Organization (WHO) (1990) defines palliative care as ‘the active total care of patients and their families by a multiprofessional team when the patient’s disease is no longer responsive to curative treatment.’ In occupational therapy there is not a finite point between acute and palliative care. The focus may change from one to the other as the client progresses or deteriorates. Symptoms are approached in a similar manner and treatment depends on the client’s functional status. Dysfunction may be the result of the tumour and/or side-effects of medical intervention such as chemotherapy, radiotherapy or surgery.
CLASSIFICATION OF TUMOURS
Tumours are classified according to histogenesis – the tissues and cells where they originate. Cancers are often described in terms of degrees of differentiation. The tumour’s degree of differentiation is the extent to which it resembles the normal tissue from which it is derived. If it closely resembles the normal tissue it is well differentiated, otherwise it is poorly differentiated. When tumour cells lose all similarity to the corresponding normal tissue, they are referred to as undifferentiated or anaplastic. Tumours of the muscle and connective tumours are classified as in Table 1.1.
Table 1.1 Nomenclature of connective tissue and muscle tumours
Fibrous tissue | Fibroma | Fibrosarcoma |
Adipose (fatty) tissue | Lipoma | Liposarcoma |
Bone | Osteoma | Osteosarcoma |
Cartilage | Chondroma | Chondrosarcoma |
Connective tissue near joints | Benign synovioma | Synovial sarcoma |
Blood vessel endothelium | Haemangioma | Haemangiosarcoma |
Lymph vessel endothelium | Lymphangioma | Lymphangiosarcoma |
Smooth muscle | Leiomyoma | Leiomyosarcoma |
Striated muscle | Rhabdomyoma | Rhabdomyosarcoma |
INCIDENCE
The incidence of cancer is increasing possibly due to lifestyle and the increasing age of the population (Gabriel, 2004, p. 11). There are 1 : 250 men and 1 : 300 women diagnosed as suffering from cancer every year (Souhami and Tobias, 2003). As the elderly population grows and as more people with cancer live longer due to better treatment, there are increasing numbers of people with residual dysfunction and disabilities who require occupational therapy. Although the treatment and management of the primary tumour have obviously been the main focus of medical input, metastatic spread is still the main cause of death (Woodhouse et al., 1997). This spread often develops before diagnosis and treatment have begun, so prognosis is not altered by treatment of the primary cancer.
The highest recorded incidences of cancers in females in England in 2002 are breast, lung and colorectal cancers. Those in males are prostate, lung and colorectal cancers (Office for National Statistics, 2005). Early intervention with cancer treatment invariably has a better chance of survival.
AETIOLOGICAL FACTORS
In many types of cancer there is still no clear evidence of what triggers the initial malignant change. Some factors are known: they are listed in Table 1.2.
Diet is emerging as an increasingly important risk factor for lower bowel cancers.
Table 1.2 Aetiology of cancer
Atomic bomb and nuclear accidents | Acute leukaemia and breast cancer |
X-rays | Acute leukaemia, squamous cell skin carcinoma |
Ultraviolet irradiation | Basal cell carcinoma, squamous cell skin carcinomas, melanoma |
Background irradiation | Acute leukaemia |
Atmospheric pollution with polycytic hydrocarbons | Lung cancer |
Cigarette smoking | Lung cancer, laryngeal cancer, bladder cancer |
Asbestos | Mesothelioma, bronchial carcinoma, lung cancer |
Arsenic | Lung cancer, skin cancer |
Aluminium | Bladder cancer |
Aromatic amines | Bladder cancer |
Benzene | Erythroleukaemia |
Polyvinyl chloride | Angiosarcoma of the liver |
SYMPTOMS
Figure 1.1 Common symptoms and signs of cancer
INVESTIGATIONS
SCREENING
Breast and cervical cancer screening is well established; breast cancer screening is only certain for females aged over 50 years. Cervical screening programmes are offered as often as resources allow. Trials have failed to show efficacy for lung cancer screening, and testicular cancer has such a good cure rate that screening could only enhance prognosis.
STAGING
Staging identifies the stage that the disease has reached and is one way of establishing the factors that are likely to influence prognosis in any individual. The TNM system evaluates the tumour by size, lymph node spread and presence of distance metastases:
T – tumour size, site and depth of the primary tumour’s invasion depending on the type of tumour, evaluated on a scale ranging from T1–T5;
OTHER INVESTIGATIONS
The individual undergoes many of the following investigations in order for diagnosis and treatment procedures to be established:
- x-ray
- blood counts
- enzymes
- ultrasound
- computed tomography (CT) scan
- positron emission tomography (PET) scan
- magnetic resonance imaging (MRI) scan
- isotope scanning
- surgery.
TREATMENTS/INTERVENTIONS
SURGERY
Cancer surgery is classified as:
- diagnostic and staging – biopsy taken. Primarily curative, where local control of cancer is essential as the primary site either causes or contributes substantially towards death;
- adjuvant – used alongside chemotherapy and/or radiotherapy;
- prophylactic – laser surgery to remove premalignant cells and preventing further tumour growth;
- reconstructive – to rebuild areas removed by other surgery;
- palliative – used in symptom control if a tumour compresses other areas or a nerve block is required for pain control;
- emergency – to remove a life-threatening obstruction;
- surgery for metastases;
- surgery for vascular access – insertion of Hickman line (central intravenous line) in the superior vena cava or right atrium through which chemotherapy can be given. Also insertion of feeding gastrostomy;
- laser surgery.
RADIOTHERAPY
Radiotherapy is the use of ionizing radiation to destroy cancer cells. The aim is to destroy or inactivate cancer cells while preserving the integrity of normal tissues within the treatment field. It is often able to control the tumour with minimal physiological disturbance. There are different types of radiotherapy, and these should be matched to the individual’s diagnosis and needs. The factors taken into account when planning radiotherapy include the type and stage of tumour, localization of tumour and adjacent normal structures.
Detailed planning is needed and this may include the preparation of an individually moulded cast. The individual wears this during radiotherapy and it positions him or her correctly. The exact positioning and dosage of radiotherapy is calculated. Radiographers position the individual on the couch, using marks made on the skin in indelible ink, and the radiation beam is switched on. Radiographers or radiotherapists observe the individual via a window or closed-circuit TV in the treatment area, using an intercom for communication.
Radiotherapy is used alone or adjuvant to surgery and/or chemotherapy. In addition to treating localized tumours it is often used as a palliative treatment to relieve pain or bleeding, or to suppress bone metastases which are developing into pathological fractures. Side-effects may include:
- fatigue and malaise, sometimes caused by bone marrow depression;
- anorexia, nausea and vomiting;
- alopecia;
- inflammation around the site being treated, causing internal side-effects such as mucositis, oesophagitis, laryngitis, diarrhoea, cystitis;
- anxiety and altered body image.
CHEMOTHERAPY
Chemotherapy is the use of cytotoxic (cell poisoning) drugs to kill cancer cells. The drugs enter the bloodstream and destroy cancer cells by interfering with the cells’ ability to grow and divide. Although normal cells can be damaged, most healthy tissue grows back again.
Chemotherapy can be used in the following ways:
- neo-adjuvant – given prior to surgery to shrink the tumour with the aim of making surgery easier as there is less tumour and increased likelihood of cure;
- adjuvant – in combination with radiotherapy or surgery to eliminate micrometa...