Basic Pharmacokinetics and Pharmacodynamics
An Integrated Textbook and Computer Simulations
Sara E. Rosenbaum, Sara E. Rosenbaum
- English
- ePUB (mobile friendly)
- Available on iOS & Android
Basic Pharmacokinetics and Pharmacodynamics
An Integrated Textbook and Computer Simulations
Sara E. Rosenbaum, Sara E. Rosenbaum
About This Book
Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. ā¢ Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner
ā¢ Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules
ā¢ Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/
ā¢ Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications
ā¢ Reviews of the 1st edition: "This is an ideal textbook for those starting out ā¦ and also for use as a reference book ā¦." (International Society for the Study of Xenobiotics) and "I could recommend Rosenbaum's book for pharmacology students because it is written from a perspective of drug action... Overall, this is a well-written introduction to PK/PD ā¦. " (British Toxicology Society Newsletter)
Frequently asked questions
Information
CHAPTER 1
Introduction to Pharmacokinetics and Pharmacodynamics
- 1.1 Introduction: Drugs and Doses
- 1.2 Introduction to Pharmacodynamics
- 1.2.1 Drug Effects at the Site of Action
- 1.2.1.1 Interaction of a Drug with Its Receptor
- 1.2.1.2 Postreceptor Events
- 1.2.2 Agonists, Antagonists, and ConcentrationāResponse Relationships
- 1.2.1 Drug Effects at the Site of Action
- 1.3 Introduction to Pharmacokinetics
- 1.3.1 Plasma Concentration of Drugs
- 1.3.2 Processes in Pharmacokinetics
- 1.4 DoseāResponse Relationships
- 1.5 Therapeutic Range
- 1.5.1 Determination of the Therapeutic Range
- 1.6 Summary
- Reference
Objectives
- Define pharmacodynamics and pharmacokinetics
- Understand the processes that control the doseāresponse relationship
- Gain a general appreciation of how mathematical expressions in pharmacodynamics and pharmacokinetics can be used for the rational determination of optimum dosing regimens
1.1 Introduction: Drugs and Doses
Drug | Daily Dose (mg) | Dose Frequency (h) | Route |
Calcium carbonate | 3000 | 2 | Oral |
Ibuprofen | 1600 | 6 | Oral |
Vancomycin (for MRSAa) | 2000 | 12 | Intravenous |
Amoxicillin | 750 | 8 | Oral |
Vancomycin (for pseudomembranous colitis) | 1000 | 6 | Oral |
Atenolol | 100 | 24 | Oral |
Fluoxetine | 20 | 24 | Oral |
Ramipril | 10 | 12 | Oral |
Digoxin | 0.250 | 24 | Oral |
Chloroquine | 300 | Weekly | Oral |