William J. Reagan, Armando R. Irizarry Rovira, Dennis B. DeNicola
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Veterinary Hematology
Atlas of Common Domestic and Non-Domestic Species
William J. Reagan, Armando R. Irizarry Rovira, Dennis B. DeNicola
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About This Book
Now in its third edition, Veterinary Hematology: Atlas of Common Domestic and Non-Domestic Species continues to offer veterinarians and veterinary technicians an essential guide to veterinary hematology. Comprehensive in scope, the atlas presents the fundamentals of both normal and abnormal blood cell morphologies, with coverage of a wide range of species, including dogs, cats, horses, ruminants, llamas, rats, mice, nonhuman primates, ferrets, rabbits, guinea pigs, birds, amphibians, and reptiles.
Designed as a useful and accessible guide, the updated third edition presents more than 300 color images and includes a new chapter that describes the best techniques for using hematology instruments.The authorsânoted experts on the topicâclearly show how to identify and interpret the hematological changes that may occur in a variety of species. In addition, a companion website offers a wealth of additional hematological images. This vital atlas:
Provides an updated edition of the popular veterinary hematology atlas for veterinarians, veterinary students, and veterinary technicians
Contains a new instructive chapter on hematology instrumentation
Presents hundreds of high-quality color photographs that help in identification
Covers a range of species from dogs and cats to birds and reptiles
Features a companion website that provides a wealth of hematological images
Written for both novice and experienced veterinarians, Veterinary Hematology provides a complete resource to blood morphologic abnormalities in domestic and non-domestic species.
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All blood cells have a finite life span, but in normal animals, the number of cells in circulation is maintained at a fairly constant level. To accomplish this, cells in circulation need to be constantly replenished, which occurs via the production and release of cells from the bone marrow. Production sites in the bone marrow are commonly referred to as medullary sites. In times of increased demand, production can also occur outside the bone marrow in sites such as spleen, liver, and lymph nodes. These sites are called extramedullary sites. In rodents, in the normal steady state, extramedullary production of blood cells occurs in the spleen.
Hematopoiesis, the production of blood cells, is a complex and highly regulated process. Some differences in hematopoiesis exist between species and are beyond the scope of this text; readers are referred to the detailed coverage in some of the references in Bibliography section. The dog will be used to demonstrate some of the basic principles of hematopoiesis. All blood cells in the bone marrow arise from a common stem cell. This pluripotent stem cell gives rise to several stages of committed progenitor cells, which then differentiate into cells of the erythrocytic, granulocytic, megakaryocytic, and agranulocytic (monocytic and lymphocytic) lineages. The end result of this development process is the release of red blood cells, white blood cells, and platelets into the circulation. At the light microscopic level, without the use of immunocytochemistry or enzyme cytochemistry, it is impossible to accurately identify the early stem cells in the bone marrow, but the more differentiated stages of development can be identified and are graphically depicted in Figure 1.1.
Figure 1.2 shows a histological section of a bone marrow core biopsy from an adult dog. Note that there is a mixture of approximately 50% hematopoietic cells and 50% fat that is surrounded by bony trabeculae. The specific types of bone marrow cells can be difficult to recognize in histological sections at this low-power magnification, but the very large cells present are megakaryocytes. Cells are easier to identify on a smear from a bone marrow aspirate (Figure 1.3). The cells that are present include erythrocytic and granulocytic precursors and a megakaryocyte. To classify these three different cell types, there are some general features that can be used. Megakaryocytes are easy to distinguish by their very large size; the majority of them are 100â200 Îźm in diameter compared with approximately 20â30 Îźm for the largest granulocytic or erythrocytic precursors.
Cells of the erythrocytic lineage can be initially distinguished from those of the granulocytic lineage on the basis of their nuclear shape and color of cytoplasm (Figures 1.4 and 1.5). Cells of the erythrocytic lineage have very round nuclei throughout most stages of development. In contrast, the nuclei of cells of the granulocytic lineage become indented and segmented as they mature. In addition, the cytoplasm of early erythrocytic precursors is much bluer than that of the granulocytic precursors.